Wash and the wash regulatory complex function in nuclear envelope budding

To wash or not to wash? That is the question.

books on sport medicine. I am not bragging about this but simply stating an easily verifiable fact. I had recently been reading a newspaper article that noted that the second biggest killer of children in the world is not malaria or tuberculosis, nor AIDS. It is diarrhoea. Over 2000 children die every single day throughout the world from this problem. The simplest solution to reducing this dise...

Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer

Wiskott-Aldrich syndrome protein (WASPs) control actin dynamics in cellular processes, including cell motility, receptor-mediated endocytosis, bacterial invasion, and vesicular trafficking. We demonstrated that WASH, a recently identified WASP family protein, colocalizes on endosomal subdomains with the cargo-selective complex (CSC) of the retromer, where it regulates retrograde sorting from en...

Integrating Wash and Nutrition

Undernutrition is the underlying cause of 45 percent of child deaths each year.1 The term undernutrition covers three primary anthropometric measures: stunting, which is low height for age; wasting, which is low weight for height; and underweight, which is low weight for age. Despite targeted and comprehensive nutrition-specific interventions, the persistent presence of undernutrition globally ...

The Power of Wash

Wash Interacts with Lamin and Affects Global Nuclear Organization

The cytoplasmic functions of Wiskott-Aldrich syndrome family (WAS) proteins are well established and include roles in cytoskeleton reorganization and membrane-cytoskeletal interactions important for membrane/vesicle trafficking, morphogenesis, immune response, and signal transduction. Misregulation of these proteins is associated with immune deficiency and metastasis [1-4]. Cytoplasmic WAS prot...